Interactions of ferrimagnetic glass/glass-ceramics with bovine serum albumin

Glasses/glass-ceramics with nominal composition 34 SiO2–(45 − x)CaO–16P2O5–4.5MgO–0.5CaF2 − xFe2O3 (where x = 10, 15, 20 wt%) have been prepared by melt quenching technique. These are characterized for structural and micro structural properties by using XRD and Raman spectroscopy. Interaction of glass-ceramics samples with bovine serum albumin (BSA) has been studied using SEM and TOF-SIMS. The formation of magnetite, apatite and wollastonite phases are observed. Typical sizes of crystallites as seen from SEM measurement are 30–50 nm. The progressive addition of iron oxide to glass leads to increase in number of non-bridging oxygen, which in turn affects the response of glass-ceramics when immersed in BSA. The samples with 15 and 20 wt% Fe2O3 have shown nearly full surface coverage with BSA, while the sample with 10 wt% Fe2O3 shows poor adhesion.