MCP-1 (monocyte chemoattractant protein-1) concentrations in patients on hemodialysis.An observational study

Monocyte chemoattractant protein-1 (MCP-1) is the main representative of chemokines, whose the main function is to direct the migration of circulating leukocytes to sites of inflammation.The present study focuses on the intra- and interdialytic MCP-1 changes in patients on hemodialysis. We studied 76 stabled dialyzed patients (47 males / 29 females) and 24 healthy subjects.The treatment modalities which were applied were: regular hemodialysis (HD, n=34) and predilution hemodiafiltration (HDF, n=42) using synthetic high-flux dialysis membranes.Four blood samples were drawn (pre-hemodialysis, 2 hours, 4 hours and 44 hours after the beginning of the mean weekly dialysis session) and serum MCP-1 concentrations were measured using ELISA.MCP-1 levels were not found higher compared to control group (p=NS), but significantly changed over time (p < 0.05).The hemodialysis modality or the material of used dialysis membranes did not influence the observed changes of MCP-1 over time (p=NS).In conclusion, MCP-1 serum concentrations in stabled patients on permanent hemodialysis treatment were significantly changed over time independently on the hemodialysis modality, despite the pre-dialysis MCP-1 mean value was similar to those in healthy subjects.