Title of article
Oncogene-Induced Senescence Pathways Weave an Intricate Tapestry
Author/Authors
Paul Yaswen، نويسنده , , Judith Campisi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
2
From page
233
To page
234
Abstract
The induction of cellular senescence by activated oncogenes acts as a barrier to cell transformation. Now, identify a key component of a senescence pathway that prevents tumorigenesis in a mouse model of skin cancer. They show that the p38-regulated/activated protein kinase (PRAK) induces senescence downstream of oncogenic Ras by directly phosphorylating and activating the tumor-suppressor protein p53.
Journal title
CELL
Serial Year
2007
Journal title
CELL
Record number
1018498
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