LUSH Shapes Up for a Starring Role in Olfaction

In the fruit fly Drosophila, odorant-binding proteins are secreted into the fluid that bathes olfactory neurons. now challenge the assumption that the odorant-binding protein LUSH passively transports its pheromone to a specific olfactory receptor. Instead, LUSH undergoes a conformational change upon pheromone binding that is sufficient for neuronal activation.