Simultaneous polarographic analysis of pyrazine and its methyl derivatives by iterative target transformation factor analysis

The polarographic waves of pyrazine and its methyl derivatives are seriously overlapping, so they cannot be determined individually by polarographic methods without a prior separation. In this paper, a chemometric approach, iterative target transformation factor analysis (ITTFA), is developed and applied to the determination of mixtures of pyrazines at trace level (2.0–9.0 × 10−6 mol l−1) by using differential pulse polarography (DPP) and a static mercury drop electrode (SMDE). Different from the general ITTFA method, only one-dimensional measurement data of n− 1 standards and an unknown were used in this work. It produced acceptable results with average recoveries in the 96–108% range and relative standard errors in the 3.4–9.5% range.