Electro-Oxidation and Determination of Amoxicillin in Drugs by a Copper Electrode

The electro-oxidation of amoxicillin (AC) on a copper electrode in alkaline solution (0.1M NaOH) has been studied by the methods of cyclic voltammetry, differential pulse voltammetry (DPV) and chronoamperometry. It has been found that in the course of an anodic potential sweep the electro-oxidation of ACd -2 (dissociated form of AC) follows the formation of CuIII and catalysed by species through a mediated electron transfer mechanism. The process is diffusion controlled and the current-time responses follow Cottrellian behavior. The rate constant and anodic transfer coefficient is reported. Also It has been described the determination of AC in pharmaceutical formulation by using DPV detection. The detection limit is 1.2 ?M (S/N=3) by DPV. The analytical utility of this electrode is simple also it was achieved by analyzing the content of AC in different drug samples with out pretreatment using DPV technique.