Polarographic determination of cisapride and cinitapride Original Research Article

A method for the determination of cinitapride by differential pulse polarography and adsorptive stripping voltammetry (ASV) in Britton–Robinson buffer, with 3s detection limits of 1.3×10−8 and 8.4×10−10 M, respectively, is described. ASV was applied for the determination of cinitapride in urine samples with an accumulation time of 65 s. A method is also proposed for the polarographic determination of cisapride in which the electroactive product is obtained by nitration with potassium nitrate in sulphuric acid. The 3s detection limit is 1.8×10−7 M and the relative standard deviation 1%.