Cleaning validation in the toiletries industry Original Research Article

Demonstration with a suitable quantitative analytical technique (liquid chromatography, LC), that application of routine cleaning procedures to toiletries production equipment (preparation and storage tanks, filling nozzles and utensils) assures the absence of the previously manufactured product. A quality assurance approach is described, from preparation of a suitable protocol of actions, to the qualification of analytical results at detection and quantitation limits. The analytical method used showed satisfactory sensitivity for the determination of residues of the selected “worst case” (a sunscreen product containing ethylhexyl (octyl) methoxycinnamate, OMC).