Title of article
Glacial acetic acid as an efficient catalyst for simple synthesis of dindolylmethanes
Author/Authors
El-Sayed، Mardia نويسنده Applied Organic Chemistry Department, National Research Centre, Cairo, Egypt , , Mahmoud، Kazem نويسنده Research group of Drug Development and Analysis, Institute of Pharmacy, Martin-Luther University-Halle, Weitenberg, Halle (Saale), Germany , , Hilgeroth، Andreas نويسنده Research group of Drug Development and Analysis, Institute of Pharmacy, Martin-Luther University-Halle, Weitenberg, Halle (Saale), Germany ,
Issue Information
فصلنامه با شماره پیاپی 9 سال 2014
Pages
8
From page
7
To page
14
Abstract
Glacial acetic acid as a protic acid was employed as a catalyst in a solvent free condition for facile preparation of di(indolyl)methanes (DIMs) via one-pot condensation of indole with aryl or heteroaryl aldehydes. Various aryl and heteroaryl aldehydes were efficiently converted to the corresponding di(indolyl)methanes (1a-p) in high yields. The described novel synthetic method proposes several advantages of safety, mild condition, short reaction times, high yields, simplicity and the inexpensively glacial acetic acid compared to other catalysts.
Journal title
Current Chemistry Letters
Serial Year
2014
Journal title
Current Chemistry Letters
Record number
1037978
Link To Document