Gold nanoshell density variation with laser power for induced hyperthermia

The thermal profile effects of nanoshell density, laser power, and laser arrangement are presented for ideal cases of nanoshell-assisted photothermal therapy. A one-dimensional thermal model utilizing the P1 approximation is used to simulate the penetration of laser radiation and subsequent heating of 1-cm slabs of nanoshell-embedded tissue exposed to a 633-nm collimated light source. It is shown that adding too many nanoshells or increasing power can cause overheating in the entry region while leaving the rear region heated only by conduction, producing an undesirable temperature differential. An opposing dual-laser approach is presented that mitigates this issue.