Title of article
Towards a Biomimetic Synthesis of the Marine Alkaloids Papuamine and Haliclonadiamine: Model Studies
Author/Authors
Robert M. Adlington، نويسنده , , Jack E. Baldwin، نويسنده , , Gregory L Challis، نويسنده , , Rhona J Cox، نويسنده , , Gareth J. Pritchard، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
6
From page
623
To page
628
Abstract
A plausible biosynthetic pathway for the isomeric marine alkaloids papuamine and haliclonadiamine via the double tandem ene cyclisation of a tetraenediimine is proposed. Initial model studies directed toward the biomimetic synthesis of these alkaloids are described which illustrate that the Lewis acid-promoted ene cyclisation of methyl-2-(methoxycarbonyl)dodeca-2,8-dienoate is critically dependent on the Δ-8 geometry.
Keywords
steric and strain effects , dienes , enals , ene reactions
Journal title
Tetrahedron
Serial Year
2000
Journal title
Tetrahedron
Record number
1080530
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