Title of article
Chemoenzymatic Synthesis of Optically Active 2-Phenyl-2-(1H-1,2,4-triazol-1-ylmethyl)hexanenitrile
Author/Authors
Dai Sig Im، نويسنده , , Chan Seong Cheong، نويسنده , , So Ha Lee، نويسنده , , Byoung Hee Youn، نويسنده , , Seok Chan Kim، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
6
From page
1309
To page
1314
Abstract
(±)-2-Cyano-2-phenyl-1-hexanol 3 was resolved to each enantiomer using Candida rugosa and Pseudomonas fluorescens lipases in 62 and 99% ee, respectively. The absolute stereochemistry of one of the enantiomers was determined to be (S) by diastereomeric amide formation and X-ray crystallography. The resolved alcohols of (R)- and (S)-isomer were transformed to Systhane® analogues.
Keywords
Fungicide , Chemoenzymatic , Quaternary carbon , lipase-catalyzed reaction
Journal title
Tetrahedron
Serial Year
2000
Journal title
Tetrahedron
Record number
1080601
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