Four Novel Oligostilbenes from the Roots of Vitis amurensis

Two novel resveratrol trimers, amurensins C (1), D (2), and two novel resveratrol pentamers, amurensins E (3), F (4) were isolated from the roots of Vitis amurensis Rupr. Their structures and relative or absolute configurations were determined by means of spectroscopic evidence, especially HMBC and NOE experiments. 2, 3 and 4 are new types of resveratrol oligomers and are reported here for the first time. The pharmacological activities on anti-inflammation of all amurensins have been tested. Among them, compound 4 showed potent inhibition on biosynthesis of leukotriene B4 (LTB4).