Title of article
Development of a Novel Hapten for Radioimmunoassay of the Lignan, Enterolactone in Plasma (Serum). Total Synthesis of (±)-trans-5-Carboxymethoxyenterolactone and Several Analogues
Author/Authors
Taru M?kel?، نويسنده , , Jorma Matikainen، نويسنده , , Kristiina W?h?l?، نويسنده , , Tapio Hase، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
10
From page
1873
To page
1882
Abstract
A recently developed method for the analysis of the mammalian lignan, enterolactone 1, is based on time-resolved fluoroimmunoassay (TR-FIA) using an europium chelate as a label. This RIA utilizes enterolactone derivatives carrying a carboxylic acid appendage for the production of antiserum and tracer. The synthesis of 5-carboxymethoxyenterolactone 6 and analogues 5, 7 and 8 is described, and their suitability for the method are discussed.
Keywords
Lactones , Lignans , carboxylic acids and derivatives , Michael reactions
Journal title
Tetrahedron
Serial Year
2000
Journal title
Tetrahedron
Record number
1080667
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