Title of article
Copper-Catalysed Asymmetric Conjugate Addition of Organometallic Reagents to Linear Enones
Author/Authors
Simon M.W Bennett، نويسنده , , Stephen M Brown، نويسنده , , Anthony Cunningham، نويسنده , , Michael R Dennis، نويسنده , , James P Muxworthy، نويسنده , , Michael A Oakley، نويسنده , , Simon Woodward، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
9
From page
2847
To page
2855
Abstract
Methods for enantioselective 1,4-addition of main-group organometallics to linear enones are overviewed. Thiourethane and thioether 1,1′-binaphthyl-based ligands are effective for copper-catalysed 1,4-addition of ZnEt2 and AlR3 (R=Me, Et) to trans-alkyl-3-en-2-ones; enantioselectivities of up to 72% e.e. are attained. In comparison 1,4-addition of ZnEt2 to 2-cyclohexenone proceeds in up to 77% e.e. with the same ligand family.
Keywords
Asymmetric synthesis , Enones , Thioethers , thiocarbonyl compounds
Journal title
Tetrahedron
Serial Year
2000
Journal title
Tetrahedron
Record number
1080766
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