Title of article
Total Synthesis of α-Deamino-3-(β-d-glucopyranosyloxy)kynurenine
Author/Authors
H. Keith Chenault، نويسنده , , Jie Yang، نويسنده , , Douglass F. Taber، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
3673
To page
3677
Abstract
α-Deamino-3-(β-d-glucopyranosyloxy)kynurenine, a yellow, fluorescent compound isolated from human lens, was synthesized in 8 steps (10% overall yield) from commercially available 3-methoxy-2-nitrobenzaldehyde. Key events included preparation and glucosylation of methyl 4-(3-hydroxy-2-nitrophenyl)-4-oxobutanoate followed by reduction of the nitro group and deprotection.
Keywords
Natural products , lithiation , NMR , Glycosidation
Journal title
Tetrahedron
Serial Year
2000
Journal title
Tetrahedron
Record number
1080852
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