Total Synthesis of Saturated and Unsaturated di-trans-N-substituted Cyclam-based Macrocycles Through a Versatile Intermediate

A total synthesis of di-trans-N-substituted cyclam-type macrocycles through a versatile intermediate is described for the first time. This synthesis uses readily available low-cost commercial reagents. This synthesis was designed in such a way that the products and some intermediates could be selectively deprotected providing versatility both during the synthesis and for the utility of the final product. Thus, it should be possible to form cryptand molecules with trans bridges with good selectivity.