Title of article
Synthesis of Functionalized γ-Spirolactone and 2-Oxabicyclo[3.3.0]octane Derivatives from Nucleophilic Oxirane Ring Opening
Author/Authors
Margareth Rôse de L. Santos، نويسنده , , Eliezer J. Barreiro، نويسنده , , Raimundo Braz-Filho، نويسنده , , Carlos Alberto M. Fraga، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
7
From page
5289
To page
5295
Abstract
Methyl 1-(2-oxiranylmethyl)-2-oxo-1-cyclopentanecarboxylate (4) was subjected to the nucleophilic ring opening reaction, leading to the formation of the functionalized 2-oxaspiro[4.4]nonane and 2-oxabicyclo[3.3.0]octane derivatives, which are important structural sub-unit present in several classes of bioactive compounds. The products obtained were characterized on the basis of spectral data, including 1D and 2D NMR.
Keywords
?-spirolactone , ?-Butyrolactone , nuclephilic oxirane ring opening
Journal title
Tetrahedron
Serial Year
2000
Journal title
Tetrahedron
Record number
1081023
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