Title of article
Novel Guaiane Endoperoxides, Nardoguaianone A–D, from Nardostachys chinensis Roots and their Antinociceptive and Antimalarial Activities
Author/Authors
Yoshiaki Takaya، نويسنده , , Yoshie Takeuji، نويسنده , , Megumi Akasaka، نويسنده , , Osamu Nakagawasai، نويسنده , , Takeshi Tadano، نويسنده , , Kensuke Kisara، نويسنده , , Hye Sook Kim، نويسنده , , Yusuke Wataya، نويسنده , , Masatake Niwa، نويسنده , , Yoshiteru Oshima، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
6
From page
7673
To page
7678
Abstract
Four novel guaianoids, nardoguaianone A, B, C and D, were isolated from Nardostachys chinensis roots. The structures were elucidated by spectral means and chemical transformation. Antinociceptive activities of the constituents of N. chinensis, including some of the above novel compounds, were investigated by the formalin test. As a result, it was revealed that nardoguaianone A and D showed activity at the second phase of pain induced by formalin injection.
Keywords
Nardostachys chinensis , sesquiterpenoid , guaiane , antinociceptive activity , antimalarial activity , formalin test
Journal title
Tetrahedron
Serial Year
2000
Journal title
Tetrahedron
Record number
1081275
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