The Cross-Coupling Reaction of Arylboronic Acids with Chloropyridines and Electron-Deficient Chloroarenes Catalyzed by a Polymer-Bound Palladium Complex

The cross-coupling reaction of tolylboronic acids (1.3 equiv.) with chloropyridines, chloroquinoline, or activated chloroarenes having an electron-withdrawing group was carried out in toluene at 80°C in the presence of a polymer-bound PdCl2 catalyst (3 mol%) and aqueous 2 M K3PO4 (2.6 equiv.). The palladium–phosphine complex supported on a polystyrene–PPh2 resin was reused with no significant decrease in activity.