Title of article
Synthesis of 3- and 5-endo-(6-Chloro-3-pyridoxy)-methyl-2-azabicyclo[2.2.0]hexane and 3-endo-(6-Chloro-3-pyridoxy)-methyl-2-azabicyclo[2.2.0]hex-5-ene. ABT-594 Analogs
Author/Authors
Grant R Krow، نويسنده , , Jing Yuan، نويسنده , , Yuhong Fang، نويسنده , , Michael D Meyer، نويسنده , , David J Anderson، نويسنده , , Jeffrey E Campbell، نويسنده , , Patrick J. Carroll and Mohan Rao Kollipara، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
6
From page
9227
To page
9232
Abstract
Stereoselective photochemical ring closure of a 2-hydroxymethyl-1,2-dihydropyridine has been utilized for the syntheses of 3-endo-(6-Cl-3-pyridoxy)-methyl-2-azabicyclo[2.2.0]hex-5-ene and hexane analogs of the nicotinic acetylcholine receptor agonist ABT-594. The photochemical ring closure of a 4-hydroxymethyl-1,2-dihydropyridine has been utilized in the preparation of 5-endo-(6-chloro-3-pyridoxy)-methyl-2-azabicyclo[2.2.0]hexane.
Keywords
bicyclic heterocyclic compounds , Grignard reagent , Mitsunobu reaction , Stereocontrol
Journal title
Tetrahedron
Serial Year
2000
Journal title
Tetrahedron
Record number
1081441
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