Title of article
Synthesis of 5- and 6-(6-Chloro-3-pyridyl)-2-azabicyclo[2.2.0]hexanes. Epibatidine Analogs
Author/Authors
Grant R Krow، نويسنده , , Jing Yuan، نويسنده , , Qiuli Huang، نويسنده , , Michael D Meyer، نويسنده , , David J Anderson، نويسنده , , Jeffrey E Campbell، نويسنده , , Patrick J. Carroll and Mohan Rao Kollipara، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
7
From page
9233
To page
9239
Abstract
Synthetic routes to vicinal-6-(6-Cl-3-pyridyl)- and distal-5-(6-Cl-3-pyridyl)-2-azabicyclo-[2.2.0]hexane analogs of the potent nicotinic receptor agonist epibatidine are described. Both exo-regioisomers are available from a readily available 2-azabicyclo[2.2.0]hex-5-ene by way of stereoselective reductive Heck addition of the 6-Cl-3-pyridyl moiety. Stereochemical inversion of the 6- and 5-aryl groups provides entry to the endo isomers.
Keywords
Heck reaction , Stereocontrol , bicyclic heterocyclic compounds , Amines
Journal title
Tetrahedron
Serial Year
2000
Journal title
Tetrahedron
Record number
1081442
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