Title of article
Triproline Analogues of Pro-Leu-Gly-NH2 with Pro/Leu and Pro/Phe Chimeric Amino Acids in Position 2
Author/Authors
Margaret C. Evans، نويسنده , , Rodney L. Johnson، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
8
From page
9801
To page
9808
Abstract
Synthesis of the cis- and trans-isomers of the proline-leucine (3-i-Pr-Pro) and proline-phenylalanine (3-Ph-Pro) chimeric amino acids was accomplished by intramolecular reductive-cycloalkylation of the appropriate azido-olefin. These chimeric amino acids were incorporated into the triprolyl analogues of Pro-Leu-Gly-NH2: Pro-cis-3-i-Pr-Pro-Pro-NH2 (3), Pro-trans-3-i-Pr-Pro-Pro-NH2 (4), Pro-cis-3-Ph-Pro-Pro-NH2 (5), Pro-trans-3-Ph-Pro-Pro-NH2 (6).
Keywords
chimeric amino acids , triproline analogue , proline-leucine
Journal title
Tetrahedron
Serial Year
2000
Journal title
Tetrahedron
Record number
1081506
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