Title of article
Structure Elucidation of Fumagillin-Related Natural Products
Author/Authors
Judit Hal?sz، نويسنده , , Benjamin Pod?nyi، نويسنده , , Lelle Vasv?ri-Debreczy، نويسنده , , Anna Szab?، نويسنده , , Félix Hajd?، نويسنده , , Zsolt B?cskei، نويسنده , , Judit Heged?s-Vajda، نويسنده , , Andrea Gy?rb??r?، نويسنده , , Istv?n Hermecz، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
10081
To page
10085
Abstract
Fumagillin is currently the only means of treatment of microsporidiosis, which is frequent and fatal in AIDS patients. Results relating to NMR and X-ray crystallographic studies of fumagillin and the structure elucidation of three related compounds are reported. In the main impurity of fumagillin there is an exocyclic double bond instead of the spiroepoxide moiety. The solid-state and solution structures of fumagillin were compared with the conformation of fumagillin complexed to aminopeptidase-2.
Keywords
conformation , X-ray diffraction , antiparasitic activity , NMR , amebicidal activity
Journal title
Tetrahedron
Serial Year
2000
Journal title
Tetrahedron
Record number
1081535
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