Title of article
Stereoselective synthesis of dithymidine phosphorothioates using d-xylose derived chiral auxiliaries
Author/Authors
Yixin Lu، نويسنده , , George Just، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
11
From page
1677
To page
1687
Abstract
Different sized catalysts 1, 2, 5 and 7 were prepared and used as the activators in the coupling reactions of phosphoramidites with nucleosides. d-Xylose derived chiral auxiliary 22a has been synthesized and applied for the stereoselective synthesis of dithymidine phosphorothioates 27. The mechanisms of the coupling reactions are discussed.
Keywords
chiral auxiliaries , Nucleotides , diastereoselection , Phosphorothioates
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1081733
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