Title of article
Hydroxy direction of zinc carbenoid addition to a remote olefin. Analysis and improvement of 2,4-pentanediol tethered Furukawa cyclopropanation
Author/Authors
Takashi Sugimura، نويسنده , , Tohru Futagawa، نويسنده , , Masato Yoshikawa، نويسنده , , Toshifumi Katagiri، نويسنده , , Ryoso Miyashige، نويسنده , , Miki Mizuguchi، نويسنده , , Shinya Nagano، نويسنده , , Seiji Sugimori، نويسنده , , Akira Tai، نويسنده , , Takahiro Tei، نويسنده , , Tadashi Okuyama، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
5
From page
7495
To page
7499
Abstract
Zinc carbenoid addition to an olefin stereocontrolled by a chiral and remote intramolecular hydroxy group was studied in detail. Stereoselectivity as well as chemical yield of the Furukawa cyclopropanation was dramatically improved by modifications of the procedure of addition of the reagents. The structure of an active species to give the hydroxy-directed product is proposed.
Keywords
Cyclopropanation , Asymmetric synthesis , zinc carbenoid , Stereocontrol
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1082361
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