Title of article
A novel synthesis of AZT
Author/Authors
Christine Gauthier، نويسنده , , Yvan Ramondenc، نويسنده , , Gérard Plé، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
5
From page
7513
To page
7517
Abstract
A novel synthesis of AZT has been achieved from two commercial available products acetaldehyde and d-mannitol. The originality of the synthesis consists of using the powerful monovinylogation reagent, the 2-lithio-1-trimethylsiloxyethylene, and to introduce the thymine moiety and to build the furanose ring in the same and last step.
Keywords
Cyclisation , Nucleosides , Azides , Antivirals
Journal title
Tetrahedron
Serial Year
2001
Journal title
Tetrahedron
Record number
1082364
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