General synthetic methods for the preparation of pinwheel receptors

The synthesis of bis-trityl diynes, used as cooperative fluorescent chemosensors, is described. The most convenient sequence for the preparation of the sensor framework was found to be intolerant of most functionality. Therefore, an unfunctionalized framework is constructed and recognition elements are selectively installed via electrophilic substitution on an electronically differentiated key intermediate. A divergent synthesis of a general class of chemical sensors emerges. This synthetic method is highlighted by its simplicity and modularity allowing for the introduction of various recognition elements and fluorophores.