An effective contribution to functionalized pyridines synthesis by way of an unusual rearrangement of amidines

A new synthesis of 2-pyridineacetamides was developed starting from pyran-2-one N-functionalized amidines . Secondary amines reacted in a sealed tube with amidines and, by nucleophilic attack on pyran-2-one nucleus and thermal rearrangement, afforded exclusively the 2-pyridineacetamide derivatives or a mixture of amide compounds and depending on the substituents linked to C-α of the starting amidine .