Title of article
Regioselective synthesis and side-chain metallation and elaboration of 3-aryl-5-alkylisoxazoles
Author/Authors
Leonardo Di Nunno، نويسنده , , Antonio Scilimati، نويسنده , , Paola Vitale، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
7
From page
2659
To page
2665
Abstract
A number of 3-aryl-5-alkylisoxazoles have been synthesized in high yields by reacting arylnitrile oxides with free enolate ions regioselectively obtained by metallation of various alkyl methyl ketones with LDA in THF at −78°C followed by dehydration. Investigations concerning regioselective side-chain metallation and elaboration of one of them (3-phenyl-5-ethylisoxazole) have also been carried out.
Keywords
Isoxazolines , isoxazoles , metallation , Synthesis
Journal title
Tetrahedron
Serial Year
2002
Journal title
Tetrahedron
Record number
1082935
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