Title of article
Preparation of α-functionalized alkenylmagnesium reagents via a halide–magnesium exchange
Author/Authors
Jérôme Thibonnet، نويسنده , , Viet Anh Vu، نويسنده , , Laurent Bérillon، نويسنده , , Paul Knochel، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
13
From page
4787
To page
4799
Abstract
A general preparation of alkenylmagnesium derivatives bearing an electron-withdrawing function in the α-position (Y=CN, CO2R, CONR2, SO2Ph) has been made possible by using a low temperature (−40 to −30°C) bromine–magnesium exchange with i-PrMgBr in THF. This reaction has also been used to prepare 5-magnesiated-1,3-dioxin-4-one derivatives bearing an alkoxy substituent in β-position to the carbon–magnesium bond.
Keywords
nitrile , Sulfone , functionalized Grignard reagents , Magnesium
Journal title
Tetrahedron
Serial Year
2002
Journal title
Tetrahedron
Record number
1083167
Link To Document