Reaction of 2-hetarylacetonitriles with ethyl 2-alkylsulfanyl-4-chloro-5-pyrimidinecarboxylates. Synthesis of new condensed pyrimidines

Reactions of 2-hetarylacetonitriles with ethyl 2-alkylsulfanyl-4-chloro-5-pyrimidinecarboxylates were studied. The interaction of pyridine, benzimidazole and benzothiazole derivatives affords a series of new condensed pyridopyrimidines . In the case of benzoxazole- and 4-arylthiazole derivatives ethyl 4-[(2-hetaryl)-cyano-methyl]-2-alkylsulfanylpyrimidine-5-carboxylates were formed. Reactions of quinazoline derivatives afford stable intermediates which formed the cyclic compound of angular structure in the presence of potash. The influence of the basicity of heterocycles and of steric factors on the intramolecular acylation reaction was studied.