Title of article
Solid and solution phase syntheses of the 2-cyanopyrrolidide DPP-IV inhibitor NVP-DPP728
Author/Authors
Nicolas Willand، نويسنده , , Jurgen Joossens، نويسنده , , Jean-Claude Gesquière، نويسنده , , André L Tartar، نويسنده , , D.Michael Evans، نويسنده , , Michael B. Roe، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
6
From page
5741
To page
5746
Abstract
DPP-IV inhibitors have been suggested as potential new treatments for type-II diabetes and 2-cyanopyrrolidides have been reported as potent DPP-IV inhibitors. Alternative synthetic approaches to one such compound, NVP-DPP728, are investigated here. One strategy is based in solution phase and is amenable to scale-up. The other is based on solid phase and is appropriate for the rapid analoging of the structural series.
Keywords
DPP-IV inhibitor , cyanopyrrolidide , NVP-DPP728
Journal title
Tetrahedron
Serial Year
2002
Journal title
Tetrahedron
Record number
1083269
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