Title of article
Paradisin C: a new CYP3A4 inhibitor from grapefruit juice
Author/Authors
Tomihisa Ohta، نويسنده , , Takuro Maruyama، نويسنده , , Minoru Nagahashi، نويسنده , , Yasuyo Miyamoto، نويسنده , , Shinzo Hosoi، نويسنده , , Fumiyuki Kiuchi، نويسنده , , Yasushi Yamazoe، نويسنده , , Sachiko Tsukamoto، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
5
From page
6631
To page
6635
Abstract
A new furanocoumarin derivative, paradisin C, was isolated from grapefruit juice as an inhibitor of cytochrome P450 (CYP) 3A4. Its stereochemistry was elucidated by spectroscopic methods. The stereochemistries of 17,18-dihydroxybergamottin and 17-epoxybergamottin were also elucidated.
Keywords
grapefruit juice , furanocoumarin , CYP3A4 inhibition , absolute stereochemistry , paradisin
Journal title
Tetrahedron
Serial Year
2002
Journal title
Tetrahedron
Record number
1083355
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