Title of article
Stereoselective synthesis of some novel heterocyclic estrone derivatives by intramolecular 1,3-dipolar cycloaddition
Author/Authors
Eva Frank، نويسنده , , J?nos W?lfling، نويسنده , , Beatrix Aukszi، نويسنده , , Verena K?nig، نويسنده , , Thomas R Schneider، نويسنده , , Gyula Schneider، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2002
Pages
7
From page
6843
To page
6849
Abstract
16,17-seco-3-Methoxyestra-1,3,5(10),16-tetraen-17-al undergoes intramolecular nitrone 1,3-dipolar cycloaddition with both hydroxylamine and N-methylhydroxylamine to produce a single isoxazolidine isomer in each case. The ring-closures of the hydrazones and the aldazine derived from the secoaldehyde lead to fused N-containing heterocycles via Lewis acid-induced cyclization of the intermediate azomethine imines.
Keywords
Nitrones , azomethine imines , 3-dipolar cycloaddition , Lewis acid , Stereoselective synthesis , 1
Journal title
Tetrahedron
Serial Year
2002
Journal title
Tetrahedron
Record number
1083382
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