Isodiplamine, cystodytin K and lissoclinidine: novel bioactive alkaloids from the New Zealand ascidian Lissoclinum notti

A study of the bioactive crude extract of the New Zealand ascidian Lissoclinum notti led to the isolation of the new pyridoacridine alkaloids isodiplamine (), cystodytin K () and lissoclinidine (), as well as the known pyridoacridine alkaloids diplamine () and cystodytin J () and the benzopentathiepin varacin () and related trithiane varacin A. The new alkaloids were characterised using standard spectroscopic techniques, including 2D 1H–15N NMR experiments. Pyridoacridine alkaloids were assayed for a range of biological activities including antitumour and antibiotic properties.