Title of article
First total synthesis of fumaridine
Author/Authors
Véronique Rys، نويسنده , , Axel Couture، نويسنده , , Eric Deniau، نويسنده , , Pierre Grandclaudon، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
5
From page
6615
To page
6619
Abstract
The first total synthesis of the alkaloid fumaridine is reported. The key step is the assemblage of the arylmethylene isoindolinone (E) by Horner reaction between the phosphorylated isoindolinone and the suitably substituted benzaldehyde . N-Lactam deprotection and concomitant E→Z isomerization complete the synthesis of the title compound.
Keywords
N-acyliminium , Alkaloids , ene lactams , Horner reaction , isoindolinones
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1084220
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