Title of article
Improving resins for solid phase synthesis: incorporation of 1-[2-(2-methoxyethoxy)ethoxy]-4-vinyl-benzene
Author/Authors
Sonia M Alesso، نويسنده , , Zhanru Yu، نويسنده , , David Pears، نويسنده , , Paul A Worthington، نويسنده , , Richard W.A. Luke، نويسنده , , Mark Bradley، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
7
From page
7163
To page
7169
Abstract
The preparation, characterisation and application of a series of non-grafted polystyrene (PS) resins containing a styrenic methoxypoly(ethylene glycol) (MPEG) derivative is presented. These novel PS-MPEG resins were designed to balance swelling and solvation with improved handling. The monomer, 1-[2-(2-methoxyethoxy)ethoxy]-4-vinyl-benzene, contained an inert phenyl ether linkage designed to provide broad chemical compatibility and stability, yet imparting all the favourable properties of the PEG group into the new resin, whilst maintaining a high loading capacity. The synthetic performance of the new resins compared very favourably to those of TentaGel™, ArgoGel™ and aminomethyl PS.
Keywords
Monomer , Solid phase synthesis , Resins , solid supports , styrenic methoxypoly(ethylene glycol) (MPEG)
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1084264
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