Title of article
Facile synthesis of a cis–syn thymine dimer building block and its incorporation into oligodeoxynucleotides
Author/Authors
Javier Ulises Ortiz Mayo، نويسنده , , Martial Thomas، نويسنده , , Carole Saintomé، نويسنده , , Pascale Clivio، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
7
From page
7377
To page
7383
Abstract
The synthesis of a building block containing the photobiologically relevant cis–syn thymine cyclobutane photoproduct and its incorporation into oligonucleotides by the phosphoramidite-based solid-phase synthesis is reported. Compared to previous syntheses, this route is extremely short and allows such modified oligonucleotides to be easily available for biological studies.
Keywords
Oligonucleotides , DNA damage , thymine dimer , Photoproducts
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1084284
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