Title of article
Novel design of a pentacyclic scaffold as structural mimic of saframycin A
Author/Authors
Chi-Wi Ong، نويسنده , , Yu An Chang، نويسنده , , Jing-Yun Wu، نويسنده , , Chien-Chung Cheng، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
5
From page
8245
To page
8249
Abstract
The design, synthesis and evaluation of a pentacyclic scaffold, to mimic saframycin A is described. is readily synthesized in five steps from 1,4-diacetyl-piperazine-2,5-dione and 2,5-dimethoxybenzaldehyde. was found to scission DNA, binds to bases 69–83(5′-GCAGTCAGG CACCGT-3′) of Hind III/Rsa I from plasmid pBR322 DNA in a foot-printing study and possesses anti-tumor activity.
Keywords
5a , 12a-diazapentacene , saframycin model , DNA binding and scissioning
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1084379
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