Title of article
Arabinofuranose disaccharide analogs as inhibitors of Mycobacterium tuberculosis
Author/Authors
Ashish K. Pathak، نويسنده , , Vibha Pathak، نويسنده , , Manish Kulshrestha، نويسنده , , Darren Kinnaird، نويسنده , , William J. Suling، نويسنده , , S.S Gurcha، نويسنده , , Gurdyal S Besra، نويسنده , , Robert C Reynolds، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
10
From page
10239
To page
10248
Abstract
Several octyl 5-O-(α-d-arabinofuranosyl)-α-d-arabinofuranoside disaccharide analogs substituted at the 5-position of the non-reducing end sugar were synthesized and tested in vitro against Mycobacterium tuberculosis (M.tb.), Mycobacterium avium complex (MAC) as well as in a cell free assay system for arabinosyltransferase acceptor/inhibitor activity. A few compounds showed interesting inhibitory activity in the cell free assay as well as against the whole microorganism in vitro.
Keywords
Glycosyltransferase , Inhibitors , Arabinofuranose , Mycobacterium tuberculosis
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1084574
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