Title of article
Trifluoromethyl-substituted hydantoins, versatile building blocks for rational drug design
Author/Authors
Volkmar Wehner، نويسنده , , Hans Ulrich Stilz، نويسنده , , Sergej N Osipov، نويسنده , , Alexander M. Golubev، نويسنده , , Joachim Sieler، نويسنده , , Klaus Bürger، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
8
From page
4295
To page
4302
Abstract
Preparatively simple, one-pot syntheses of trifluoromethyl-substituted hydantoins starting from Boc-protected imines of hexafluoroacetone and trifluoropyruvate are described. They represent valuable building blocks for the construction of constrained peptides or as scaffolds for the synthesis of highly potent VLA-4 antagonists.
Keywords
domino reactions , Retro ene reaction , Lipophilic building blocks
Journal title
Tetrahedron
Serial Year
2004
Journal title
Tetrahedron
Record number
1085489
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