Title of article
Total synthesis of dehydroaltenusin
Author/Authors
Shinji Kamisuki، نويسنده , , Shunya Takahashi، نويسنده , , Yoshiyuki Mizushina، نويسنده , , Shinya Hanashima، نويسنده , , Kouji Kuramochi، نويسنده , , Susumu Kobayashi، نويسنده , , Kengo Sakaguchi، نويسنده , , Tadashi Nakata، نويسنده , , Fumio Sugawara، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
6
From page
5695
To page
5700
Abstract
The first total synthesis of dehydroaltenusin, a natural enzyme inhibitor, is described. The key step involves Suzuki-coupling reaction of an aryl triflate prepared from 2,4,6-trihydroxybenzoic acid with a catechol-derived boronic acid or boronic ester. The synthetic product was evaluated as a potent inhibitor against eukaryotic DNA polymerase α and other DNA polymerases.
Keywords
Dehydroaltenusin , DNA polymerase ? , Enzyme inhibitor
Journal title
Tetrahedron
Serial Year
2004
Journal title
Tetrahedron
Record number
1085773
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