Title of article
Buffer-induced, selective mono-C-alkylation of phloroglucinol: application to the synthesis of an advanced intermediate of catechin
Author/Authors
Arnaud Gissot، نويسنده , , Alain Wagner، نويسنده , , Charles Mioskowski، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
6
From page
6807
To page
6812
Abstract
A straightforward mono-selective and C-specific alkylation of phloroglucinol with activated alkyl halides is presented. The use of water as solvent limits the amount of over-alkylated by-products. Provided some minor changes in the experimental conditions, hydrophobic cinnamyl halides can also be reacted, thus giving a direct access to advanced intermediates of natural flavonoids.
Keywords
Synthetic methodology , Flavonoids , Polyphenol compounds , phloroglucinol , Alkylation
Journal title
Tetrahedron
Serial Year
2004
Journal title
Tetrahedron
Record number
1085878
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