Title of article
α-Hydroxy carboxylic acids as ligands for enantioselective diethylzinc additions to aromatic and aliphatic aldehydes
Author/Authors
Tomasz Bauer، نويسنده , , Joanna Gajewiak، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
8
From page
9163
To page
9170
Abstract
The first examples of the enantioselective titanium-mediated diethylzinc additions to aromatic and aliphatic aldehydes catalyzed by optically active α-hydroxy acids are presented. The reactions proceed with very good yield and good asymmetric induction. Enantioselectivities up to 90% are obtained depending on ligand and aldehyde used. A stereochemical model for the reaction is proposed.
Keywords
Aldehydes , Titanium tetraisopropoxide , Enantioselective , Diethylzinc , ?-hydroxy acids
Journal title
Tetrahedron
Serial Year
2004
Journal title
Tetrahedron
Record number
1087129
Link To Document