Title of article
The synthesis of ketolide antibiotic ABT-773 (cethromycin)
Author/Authors
Daniel J. Plata، نويسنده , , M. Robert Leanna، نويسنده , , Michael Rasmussen، نويسنده , , Maureen A. McLaughlin، نويسنده , , Steven L. Condon، نويسنده , , Francis A.J. Kerdesky، نويسنده , , Steven A. King، نويسنده , , Matthew J. Peterson، نويسنده , , Eric J. Stoner، نويسنده , , Steven J. Wittenberger، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2004
Pages
10
From page
10171
To page
10180
Abstract
A practical and efficient synthesis of ketolide antibiotic cethromycin (ABT-773) () is described. An effective protection strategy allows high yielding, regioselective C6-O-alkylation and subsequent stereoselective modification of the erythromycin nucleus. ABT-773 was prepared in 10 steps from commercially available erythromycin A oxime.
Keywords
Macrolides , ABT-773 , Cethromycin
Journal title
Tetrahedron
Serial Year
2004
Journal title
Tetrahedron
Record number
1087224
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