Absolute stereochemistry of amphidinolide C: synthesis of C-1–C-10 and C-17–C-29 segments

Two of each diastereomers of the C-1–C-10 and C-17–C-29 segments of amphidinolide C () were synthesized. Comparing the 1H NMR chemical shifts of its MTPA esters with those of linear methyl ester of , the absolute configurations at C-7, C-8, C-20, C-23, and C-24 in amphidinolide C () were confirmed to be all R.