Title of article
Synthesis of novel HIV-1 protease inhibitors based on carbohydrate scaffolds
Author/Authors
Paul V Murphy، نويسنده , , Julie L OʹBrien، نويسنده , , Lorraine J. Gorey-Feret، نويسنده , , Amos B. Smith III، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
13
From page
2259
To page
2271
Abstract
The synthesis of peptidomimetic inhibitors of HIV-1 protease based on 6-deoxy-6-amino-β-d-glucopyranoside and 6-deoxy-6-amino-β-d-mannopyranoside scaffolds has been achieved. The inhibitors had IC50 values in the micromolar range. The results provide a platform for the development of more potent carbohydrate based inhibitors of HIV-1 and other aspartic proteases.
Keywords
HIV-1 , Inhibitors , Aspartic acid , carbohydrate based peptidomimetics
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1087644
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