Title of article
Dynamic thermodynamic resolution of N-methylpseudoephedrine α-bromo esters for asymmetric syntheses of α-hydroxy carboxylic acid derivatives
Author/Authors
Jiyoun Nam، نويسنده , , Sang-kuk Lee، نويسنده , , Yong-Sun Park and Sang Joon Kim، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
5
From page
2397
To page
2401
Abstract
An example of dynamic thermodynamic resolution in the nucleophilic substitution reactions of α-bromo esters with an oxygen nucleophile is described. Temperature controlled epimerization–substitution sequence provides a practical protocol for the preparation of highly enantioenriched α-hydroxy carboxylic acid derivatives up to 72% yield with 99:1 er.
Keywords
dynamic thermodynamic resolution , Nucleophilic substitution , asymmetric syntheses , ?-hydroxy carboxylic acid , chiral auxiliaries
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1087656
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