Title of article
Radical cyclization; towards the syntheses of tetranor metabolites of 15-F2t-isoprostane
Author/Authors
Thierry Durand، نويسنده , , Olivier Henry، نويسنده , , Alexandre Guy، نويسنده , , Arlène Roland، نويسنده , , Jean-Pierre Vidal، نويسنده , , Jean Claude Rossi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2003
Pages
11
From page
2485
To page
2495
Abstract
Radical cyclization of acyclic 1-substituted-2,4-dihydroxylated 5-hexenyl radicals produced functionalized cyclopentane derivatives. These cyclopentanic precursors after different protection/deprotection reactions followed by Wittig and Horner–Wadsworth–Emmons coupling reactions led to the main urinary tetranor metabolites of 15-F2t-isoprostane (8-epi-PGF2α).
Keywords
tetranor metabolites , cyclopentane precursors , 15-F26-isoprostane , Radical cyclization
Journal title
Tetrahedron
Serial Year
2003
Journal title
Tetrahedron
Record number
1087668
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